New guidelines for prescribing PrEP and nPEP to prevent HIV infection have been laid out for Canadian doctors and other primary care practitioners by the Biomedical HIV Prevention Working Group of the CIHR Canadian HIV Trials Network. The guideline has been published in CMAJ. The guideline outlines how and when to prescribe PrEP and nPEP and will help increase awareness and access to research-based HIV prevention options, and decrease the incidence of HIV infection over time.